01431nas a2200313   4500000000100000008004100001260000900042653001000051653001800061653001100079653001100090653002100101653002100122653002100143653001200164653002600176653000900202653001600211653001800227100001600245700001600261700001600277700001500293245011700308300001100425490000600436520066100442022001401103       1976                            d  c197610aAdult10aB-Lymphocytes10aFemale10aHumans10aImmunoglobulin A10aImmunoglobulin G10aImmunoglobulin M10aleprosy10aLymphocyte Activation10aMale10aMiddle Aged10aT-Lymphocytes1 aBarnetson R1 aBarnetson A1 aPearson J M1 aKronvall G00aDoes nonspecific T-lymphocyte stimulation of B lymphocytes occur during reversal reaction in borderline leprosy?  a287-910 v53 a<p>Serum immunoglobulins G, A, and M were estimated in 14 patients with border-line cases of leprosy at commencement of treatment and subsequently when they developed 'reversal reaction'. There was a significant increase in all immunoglobulin levels during the reaction, with a subsequent fall; the postreaction values for IgG and IgA were below the base-line figures. Additonal investigations in six patients indicated that the rise was a nonspecific one, not brought about by an increase in antimycobacterial antibodies. It seems likely that the rise in immunoglobulins during reaction is due to nonspecific T-lymphocyte stimulation of B lymphocytes.</p>  a0300-9475