01650nas a2200265   4500000000100000008004100001260001300042653001200055653001500067653002700082653001200109100001300121700001400134700001500148700001200163700001500175700001800190700001400208700001100222245008100233300001100314490000700325520103800332022001401370       1997                            d  c1997 Nov10aAnimals10aArmadillos10aDisease Models, Animal10aleprosy1 aSasaki N1 aKawatsu K1 aTsutsumi S1 aGidoh M1 aNakagawa H1 aKashiwabara Y1 aMatsuki G1 aEndo H00aPathological investigation of armadillos infected with Mycobacterium leprae.  a227-350 v663 a<p>An infection experiment with M. leprae was carried out using 20 nine-banded armadillos. As a result, the development of leprous lesions and a marked multiplication of AFB were confirmed in a high rate of 13 out of 15 cases (86.8%) in the inoculated groups. These changes were found to be progressing at post mortem of one case even with the shortest life period for 7.5 months and were very serious in one case with the longest life period for 33 months, suggesting the continuation of symptoms, though it is an expression neglecting the individual difference in susceptibility to leprosy. Among infected viscera with AFB, the most conspicuous lesions were found in the liver and spleen. The developed lesions were found in the lung, stomach and kidney which had been never seen in HD in human cases, and so, which may characterize armadillos' leprosy. The change in the peripheral nerve was not so severe when compared with that in HD in human cases. This difference will remain as a future pathological problem to be solved.</p>  a1342-3681