01273nas a2200253 4500000000100000008004100001260000900042653002700051653002000078653001100098653002900109653003200138653001800170653001200188653003200200100001200232700001300244700001500257245012600272300001000398490000700408520059000415022001401005 1997 d c199710aDisease Susceptibility10aGenetic Linkage10aHumans10aImmunoglobulin Allotypes10aImmunoglobulin Gm Allotypes10aInterleukin-110aleprosy10aTumor Necrosis Factor-alpha1 aLevee G1 aSchurr E1 aPandey J P00aTumor necrosis factor-alpha, interleukin-1-beta and immunoglobulin (GM and KM) polymorphisms in leprosy. A linkage study. a160-50 v143 a

In order to determine the genetic components of susceptibility to leprosy in 6 multiplex French Polynesian families, linkage analysis was carried out between a putative disease gene and 6 polymorphic loci: G1M, G2M, KM, IL-1 beta, TNF-alpha (1, 2) and TNF-alpha (A, G) using the lod score method. The three modes of inheritance, assuming a full penetrance value or reduced penetrance values (80 and 40%) for the susceptible allele, as well as with affected ones only, were tested. The results of this study provide no evidence for linkage between leprosy and the markers tested.

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