02144nas a2200373   4500000000100000008004100001260001300042653002200055653001200077653001600089653001200105653003000117653001100147653005300158653002400211653002100235653002300256653001200279653000900291653002400300653001500324653001400339653001500353100001200368700001400380700001100394700001200405245025900417856004100676300001100717490000700728520102100735022001401756       1997                            d  c1997 Sep10aAdoptive Transfer10aAnimals10aClofazimine10aDapsone10aDrug Therapy, Combination10aFemale10aGranulocyte-Macrophage Colony-Stimulating Factor10aImmunologic Factors10aInterferon-gamma10aLeprostatic Agents10aleprosy10aMice10aMice, Inbred BALB C10aMice, Nude10aOfloxacin10aRifamycins1 aMaw W W1 aTomioka H1 aSato K1 aSaito H00aStudies on therapeutic activity of benzoxazinorifamycin KRM-1648 in combination with other antimicrobial agents and biological response modifiers interferon-gamma and granulocyte-macrophage colony-stimulating factor against M. leprae infection in athymic  uhttp://ila.ilsl.br/pdfs/v65n3a05.pdf  a345-510 v653 a<p>In the present study, we evaluated the in vivo anti-Mycobacterium leprae activities of KRM-1648 (KRM) given at long intervals in combination with ofloxacin (OFLX), clofazimine (CFZ), and dapsone (DDS). We also examined the combined effects of two biological response modifiers (BRMs), gamma interferon (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF), on the therapeutic efficacy of KRM. KRM exhibited potent therapeutic efficacy against M. leprae infection in mice even when given at 4-week intervals. KRM displayed increased efficacy in combination with OFLX, CFZ, and DDS (given three or six times per week) when given to mice in the multidrug combination KRM + OFLX + CFZ + DDS. The therapeutic efficacy of KRM given at 4-week intervals was increased by combined use with IFN-gamma but not by GM-CSF. Adoptive transfer of M. leprae antigen-primed lymphocytes of euthymic mice to recipient athymic nude mice with progressive M. leprae infection markedly enhanced host resistance.</p>
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