01911nas a2200373   4500000000100000008004100001260001300042653001500055653001000070653001100080653001000091653002000101653001500121653001100136653001400147653001100161653002500172653001600197653000900213653001600222653002500238653002200263653000900285100001200294700001500306700001600321700001500337245010400352856004100456300001000497490000700507520100900514022001401523       1997                            d  c1997 Dec10aAdolescent10aAdult10aBiopsy10aChild10aChronic Disease10aDermatitis10aFemale10aGranuloma10aHumans10aLeprosy, lepromatous10aLymphocytes10aMale10aMiddle Aged10aMycobacterium leprae10aPeripheral nerves10aSkin1 aJob C K1 aBaskaran B1 aJayakumar J1 aAschhoff M00aHistopathologic evidence to show that indeterminate leprosy may be a primary lesion of the disease.  uhttp://ila.ilsl.br/pdfs/v65n4a01.pdf  a443-90 v653 a<p>Five biopsies of patients with indeterminate leprosy and five with skin lesions of nonspecific chronic inflammation were chosen. Histopathologic changes in the presence of acid-fast bacilli (AFB) in an average number of 145 serial sections from the entire paraffin block from each were evaluated. In all five indeterminate lesions AFB were found in the dermis, but intraneural AFB were present in only two cases. Mainly, lymphocytic infiltrate was present in two and early, poorly formed granulomas were seen in three. It is suggested that nonspecific chronic inflammation of the skin could precede indeterminate disease and that AFB, before they entered the dermal nerves, may be found in other dermal tissues. In most if not all early lesions of indeterminate leprosy Mycobacterium leprae would be found if an adequate number of sections stained for AFB were examined. The histopathologic and immunologic features of indeterminate disease were in favor of it being a primary lesion in leprosy.</p>
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