02464nas a2200409   4500000000100000008004100001260001300042653001000055653001100065653003200076653002700108653001800135653001100153653004400164653001100208653001000219653001200229653000900241653002500250653002900275653002200304653003900326653006300365653001600428100001300444700000900457700001200466700001200478700001400490700001100504700001300515245007900528300001000607490000700617520141600624022001402040       2000                            d  c2000 Apr10aAdult10aBiopsy10aCharcot-Marie-Tooth Disease10aDemyelinating Diseases10aFabry Disease10aFemale10aHereditary Sensory and Motor Neuropathy10aHumans10aKorea10aleprosy10aMale10aMicroscopy, Electron10aNerve Fibers, Myelinated10aPeripheral nerves10aPeripheral Nervous System Diseases10aPolyradiculoneuropathy, Chronic Inflammatory Demyelinating10aSural Nerve1 aHong S M1 aHa H1 aSuh J H1 aKim K K1 aKhang S K1 aRo J Y1 aPark S H00aClinicopathologic analysis of 124 biopsy-proven peripheral nerve diseases.  a211-60 v153 a<p>We reviewed dinical, histological and ultrastructural findings of 124 cases of sural nerve biopsy specimens to delineate the trends of peripheral nerve diseases in our institute. Eighty-one were men and 43 were women. We categorized them into five groups: specific diagnosis (66 cases, 53.2%), axonal degeneration type (47 cases, 37.9%), demyelinating type (4 cases, 3.2%), mixed axonal degeneration-demyelinating type (6 cases, 4.8%) and normal (1 case, 0.9%). Cases with specific diagnosis included 21 inflammatory demyelinating polyneuropathy (15 chronic inflammatory demyelinating polyradiculoneuropathy, 6 Guillain-Barre disease), 13 hereditary motor and sensory neuropathy (7 Charcot-Marie-Tooth type I, 6 Charcot-Marie-Tooth type II), 10 vasculitis, 6 toxic neuropathy, 4 leprosy, 3 diabetic neuropathy, 2 alcoholic neuropathy, 1 Fabry's disease and other specific diseases (5 cases). In our cases, the proportion of specific diagnoses was higher, while the proportion of demyelinating peripheral neuropathies and normal were lower than those of Western series. The results of this study indicate that 1) a dose clinicopathologic correlation is important to make a precise diagnosis of peripheral nerve biopsy, 2) Biopsy under strict indication may reduce unnecessary histologic examination, 3) There is no difference in disease pattern of peripheral neuropathy between Western people and Koreans.</p>  a1011-8934