01855nas a2200385   4500000000100000008004100001260001300042653001200055653002100067653003000088653001100118653002000129653003800149653001100187653001200198653001400210653000900224653002200233653002700255653001300282653003000295653002600325653001400351100001200365700001200377700001500389700001400404700001300418245015900431856004100590300001200631490000700643520080500650022001401455       1997                            d  c1997 Jun10aAlleles10aCarrier Proteins10aCation Transport Proteins10aFemale10aGenetic Linkage10aGenetic Predisposition to Disease10aHumans10aleprosy10aLod Score10aMale10aMembrane Proteins10aMicrosatellite Repeats10aPedigree10apolymerase chain reaction10aPolymorphism, Genetic10aPolynesia1 aRoger M1 aLevee G1 aChanteau S1 aGicquel B1 aSchurr E00aNo evidence for linkage between leprosy susceptibility and the human natural resistance-associated macrophage protein 1 (NRAMP1) gene in French Polynesia.  uhttp://ila.ilsl.br/pdfs/v65n2a06.pdf  a197-2020 v653 a<p>In order to determine whether a human homolog (NRAMP1) to a murine candidate gene for resistance to mycobacteria influences susceptibility to human disease, we analyzed data from seven multicase leprosy families (84 individuals) from French Polynesia for linkage markers within the NRAMP1 gene and leprosy per se. Individual family members were typed at nine polymorphic loci within NRAMP1. In addition, three physically linked, polymorphic microsatellite markers-D2S104, D2S173 and D2S1471-were also typed. Linkage analyses were done using affected sibpair and LOD score methods employing different modes of inheritance with full and reduced penetrance. The results of this study strongly suggest that NRAMP1 is not linked to leprosy susceptibility in the French Polynesian families tested.</p>
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