01121nas a2200289   4500000000100000008004100001260001300042653001000055653002200065653004100087653003100128653001600159653001100175653002300186653001000209653000900219653002200228100001600250700001500266700001400281700001800295245009800313300001000411490000700421520038900428022001400817       1997                            d  c1997 Mar10aAdult10aBiotransformation10aChromatography, High Pressure Liquid10aChromatography, Thin Layer10aClofazimine10aHumans10aLeprostatic Agents10aLiver10aMale10aMass Spectrometry1 aKrishna D R1 aMamidi R N1 aHofmann U1 aPrabhakar C M00aCharacterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry.  a303-60 v473 a<p>Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.</p>  a0004-4172