01236nas a2200325   4500000000100000008004100001260001700042653001800059653001500077653002900092653001200121653002600133653001100159653001600170653001100186653002300197653001200220653001700232653001300249100001300262700001300275700001100288700001200299700001400311245007300325300000900398490000700407520048200414022001400896       2000                            d  c2000 Apr-Jun10aAcute disease10aAdolescent10aAnti-Inflammatory Agents10aDapsone10aDrug Hypersensitivity10aFemale10aHepatitis E10aHumans10aLeprostatic Agents10aleprosy10aPrednisolone10aSyndrome1 aChogle A1 aNagral A1 aSoni A1 aAgale S1 aJamadar Z00aDapsone hypersensitivity syndrome with coexisting acute hepatitis E.  a85-60 v193 a<p>A 14-year-old girl presented with fever, generalized lymphadenopathy, skin rash and hepatitis after starting dapsone. All abnormalities reversed with institution of prednisolone therapy after discontinuation of dapsone. The hepatic involvement was of hepatocellular type; it was associated with IgM anti-HEV antibodies, suggesting coexisting acute hepatitis E. We believe a causal link between the hepatotrophic viruses and dapsone hypersensitivity syndrome could exist.</p>  a0254-8860