01023nas a2200205   4500000000100000008004100001260001600042653001000058653002000068653001200088653001100100653001100111100001500122700001600137245003600153300001100189490000600200520059700206022001400803       1977                            d  c1977 Aug 2010aAdult10aAgranulocytosis10aDapsone10aFemale10aHumans1 aFirkin F C1 aMariani A F00aAgranulocytosis due to dapsone.  a247-510 v23 a<p>A case of agranulocytosis due to dapsone administered for the treatment of acne vulgaris is described. Agranulocytosis has previously been reported after administration of dapsone for other dermatological disorders, leprosy, and prophylaxis against falciparum malaria. The frequency of agranulocytoses when dapsone was used for malaria prophylaxis in United States servicemen in Vietnam was sufficient to result in its withdrawal from use for this purpose. Caution should therefore be exercised in the administration of dapsone for conditions for which less toxic agents are available.</p>  a0025-729X