01486nas a2200337   4500000000100000008004100001260001300042653001200055653001500067653001100082653002800093653001400121653002300135653002800158653002200186653001300208653001200221653000900233653002400242653001500266653002500281653000900306100001200315700001500327245012200342856004100464300001000505490000700515520061200522022001401134       2000                            d  c2000 Mar10aAnimals10aArmadillos10aBiopsy10aColony Count, Microbial10aGranuloma10aHistocytochemistry10aInjections, Intradermal10aIntradermal Tests10aLepromin10aleprosy10aMice10aMice, Inbred BALB C10aMice, Nude10aMycobacterium leprae10aSkin1 aJob C K1 aTruman R W00aComparative study of Mitsuda reaction to nude mouse and armadillo lepromin preparations using nine-banded armadillos.  uhttp://ila.ilsl.br/pdfs/v68n1a03.pdf  a18-220 v683 a<p>In 14 nine-banded armadillos the Mitsuda response to nude mouse-derived lepromin (lepromin-nu/nu) was compared to that of armadillo-derived lepromin (lepromin-A) by injecting the reagents intradermally into either side of the abdomen of the animal and examining the biopsies from the sites after 12 days. The histopathologic responses to both antigens were found to be similar, whether the animal was Mitsuda-negative (lepromatous) or Mitsuda-positive (tuberculoid). It is pointed out that armadillos are good experimental models for leprosy, and their use can replace humans in experimental studies.</p>  a0148-916X