01344nas a2200253   4500000000100000008004100001260001300042653001900055653003800074653001100112653001100123653001200134653000900146653001500155100002300170700001400193700001600207700001900223245003600242300000900278490000700287520078200294022001401076       1996                            d  c1996 Jan10aAutoantibodies10aEnzyme-Linked Immunosorbent Assay10aFemale10aHumans10aleprosy10aMale10aPrevalence1 aGuedes Barbosa L S1 aGilbrut B1 aShoenfeld Y1 aScheinberg M A00aAutoantibodies in leprosy sera.  a26-80 v153 a<p>Our objective was to assess the prevalence of autoantibodies in patients with leprosy. Forty-one cases of lepromatous leprosy were studied. For the detection of autoantibodies we used the Elisa technique using the following purified antigens in an Elisa assay: dsDNA, ssDNA, histone, mitochondria, RNA, RNP, SS-A, SS-B, Sm, Scl-70, Anca C, Anca P and the cardiolipin complex. As a "cut off" point we used values shown on previous studies to differentiate normal from elevated values. Antibodies to SS-B, mitochondria and cardiolipin were the most prevalent in our study. Antimitochondrial antibodies distinct from those seen in primary biliary cirrhosis and antiphospholipid antibodies with variable ligand activity to B2GIP are frequent in the sera of leprosy patients.</p>  a0770-3198