01971nas a2200337   4500000000100000008004100001260001300042653003600055653001900091653001700110653002000127653002000147653001100167653001000178653001200188653002500200653003000225653004600255653004900301100001100350700001300361700001600374700001500390700001200405245007400417856004100491300001000532490000700542520107000549022001401619       2000                            d  c2000 Mar10aCytotoxicity Tests, Immunologic10aDNA, Bacterial10aHLA Antigens10aHLA-DQ Antigens10aHLA-DR Antigens10aHumans10aJapan10aleprosy10aMycobacterium leprae10apolymerase chain reaction10aPolymorphism, Restriction Fragment Length10aPolymorphism, Single-Stranded Conformational1 aJoko S1 aNumaga J1 aKawashima H1 aNamisato M1 aMaeda H00aHuman leukocyte antigens in forms of leprosy among Japanese patients.  uhttp://ila.ilsl.br/pdfs/v68n1a07.pdf  a49-560 v683 a<p>Human leukocyte antigens (HLA) class II alleles were analyzed among Japanese leprosy patients to ascertain whether immunogenetic differences exist among the leprosy classification forms of Ridley and Jopling. Ninety-three unrelated Japanese leprosy patients (21 lepromatous, 24 borderline lepromatous, 17 mid-borderline, 26 borderline tuberculoid, 5 tuberculoid) and 114 healthy control subjects were investigated. The frequencies of HLA-DRB1*1501, -DRB5*0101, -DQA1*0102 and DQB1*0602 were significantly increased in all of the Japanese leprosy patients. The frequencies of HLA-DRB1*0405, -DQA1*03 and -DQB1*0401 were significantly decreased in the Japanese patients after correction of the p value. Conversely, there were no significantly different distributions of the HLA-DRB1, -DRB5, -DQA1, DQB1 alleles in the five subgroups of these patients. We conclude that HLA class II alleles were not associated with the form of leprosy. Other HLA, a non-HLA gene, and/or environmental factors may play a critical role in the different manifestations of leprosy.</p>  a0148-916X