01413nas a2200385 4500000000100000008004100001260001300042653002400055653001100079653002100090653001800111653001800129653001200147653002500159653001400184100001700198700001400215700001400229700001600243700001400259700001500273700001400288700001300302700001200315700001500327700001200342700001500354700001400369245007800383856005600461300001100517490000700528520047800535022001401013 1996 d c1996 Oct10aAntigens, Bacterial10aHumans10aInterferon-gamma10aInterleukin-410aInterleukin-510aleprosy10aMycobacterium leprae10aTh1 Cells1 aDockrell H M1 aYoung S K1 aBritton K1 aBrennan P J1 aRivoire B1 aWaters M F1 aLucas S B1 aShahid F1 aDojki M1 aChiang T J1 aEhsan Q1 aMcAdam K P1 aHussain R00aInduction of Th1 cytokine responses by mycobacterial antigens in leprosy. uhttps://iai.asm.org/content/iai/64/10/4385.full.pdf a4385-90 v643 a
Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.
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