01438nas a2200301   4500000000100000008004100001260001700042653001200059653001700071653002700088653001100115653001800126653001200144653000900156653002500165653001800190653001800208100001500226700001500241700001400256700001400270245011500284300001100399490000700410050003200417520067300449022001401122       1995                            d  c1995 Oct-Dec10aAnimals10aCyclosporine10aDemyelinating Diseases10aFemale10aIsoantibodies10aleprosy10aMice10aMycobacterium leprae10aSciatic Nerve10aT-Lymphocytes1 aShetty V P1 aMistry N F1 aBirdi T J1 aAntia N H00aEffect of T-cell depletion on bacterial multiplication and pattern of nerve damage in M. leprae-infected mice.  a363-740 v67  aInfolep Library - available3 a<p>Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion: (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.</p>  a0254-9395