01211nas a2200253 4500000000100000008004100001260001300042653002400055653001100079653001200090653002500102653002000127653001800147100001400165700001300179700002200192700001800214700002100232245010500253300001200358490000700370520056600377022001400943 1995 d c1995 Dec10aAntigens, Bacterial10aHumans10aleprosy10aMycobacterium leprae10aSerologic Tests10aT-Lymphocytes1 aThole J E1 aWieles B1 aClark-Curtiss J E1 aOttenhoff T H1 aRinke de Wit T F00aImmunological and functional characterization of Mycobacterium leprae protein antigens: an overview. a791-8000 v183 a

A major focus of leprosy research in the last 10 years has been the identification and characterization of antigens of Mycobacterium leprae that interact with antibodies and T cells of the host's immune response. Through the combined efforts of many different laboratories, a substantial number of protein antigens have been identified and characterized. In this MicroReview we present an updated list of M. leprae protein antigens, and, with emphasis on recent developments, summarize what is known regarding their functional and immunological features.

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