02060nas a2200421   4500000000100000008004100001260001300042653001500055653001000070653000900080653002600089653002400115653001000139653000900149653003800158653001100196653001600207653001100223653001200234653000900246653001600255653002500271100002100296700001200317700001600329700001700345700001400362700001700376700001300393700001700406245013500423856005900558300000900617490000700626050003200633520095900665022001401624       1996                            d  c1996 Mar10aAdolescent10aAdult10aAged10aAntibodies, Bacterial10aAntigens, Bacterial10aChild10aCuba10aEnzyme-Linked Immunosorbent Assay10aFemale10aGlycolipids10aHumans10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae1 aGonzalez-Abreu E1 aPon J A1 aHernádez P1 aRodríguez J1 aMendoza E1 aHernández M1 aCuevas E1 aGonzalez A B00aSerological reactivity to a synthetic analog of phenolic glycolipid I and early detection of leprosy in an area of low endemicity.  uhttp://leprev.ilsl.br/pdfs/1996/v67n1/pdf/v67n1a02.pdf  a4-120 v67  aInfolep Library - available3 a<p>A total of 23,863 individuals living in an area of low endemicity for leprosy were tested by enzyme-linked immunosorbent assay with a semisynthetic analogue of the phenolic glycolipid I antigen of Mycobacterium leprae. The proportion found positive was 3.86% which was significantly higher than that in a sample of a population known to be free of leprosy. Clinical examinations as well as Mitsuda and skin smear tests were organized for those defined as seropositive. The proportion of individuals with lepromin reactions of less than 3 mm increased 18.9% per serological interval as antibodies rose though it was not statistically significant. As a result of the clinical and bacteriological examinations, 2 cases with clinical signs and heavy bacillary load were found, whereas acid-fast bacilli were demonstrated in 2 other individuals without clinical manifestations of leprosy. The usefulness of the system for control purposes is discussed.</p>  a0305-7518