01584nas a2200361   4500000000100000008004100001260001700042653001000059653002600069653002400095653001000119653001100129653001100140653001300151653001200164653000900176653002500185653001900210653001300229653001800242100001100260700001600271700001900287700001400306700001900320700001600339245007600355300001000431490000700441050003200448520072800480022001401208       1996                            d  c1996 Apr-Jun10aAdult10aAntibodies, Bacterial10aAntigens, Bacterial10aChild10aFemale10aHumans10aLepromin10aleprosy10aMale10aMycobacterium leprae10aPain Threshold10aSweating10aThermosensing1 aRamu G1 aKarikeyan S1 aBalakrishnan S1 aPatil S A1 aRamanathan V D1 aDesikan K V00aHistological and immunological correlates of suspected leprosy lesions.  a155-90 v68  aInfolep Library - available3 a<p>Thirty-two subjects with suspected leprosy lesions were investigated to assess various modalities of sensibility and sweat function and these were correlated with immunological and histological parameters. It was found that pain and temperature, mediated by small unmyelinated fibres were impaired in the early lesions. Impairment of sweat function was seen only when one of the modalities of sensibility was also affected. Antibodies specific to a protein (35 kDa) antigen and phenolic glycolipid 1 of Mycobacterium leprae were positive in nine and 12 cases respectively, while 15 of the 31 biopsies revealed the presence of mycobacterial antigens in these lesions. The implications of these findings are discussed.</p>  a0254-9395