01724nas a2200277   4500000000100000008004100001260001300042653004200055653001000097653001200107653002200119653001100141653002100152653001200173653003600185653002900221653003400250653002700284653002800311100001400339245008700353300001100440490000700451520097400458022001401432       1996                            d  c1996 Jul10aAIDS-Related Opportunistic Infections10aAdult10aAnimals10aHTLV-I Infections10aHumans10aImmune Tolerance10aleprosy10aLeukemia-Lymphoma, Adult T-Cell10aOpportunistic Infections10aParaparesis, Tropical Spastic10aStrongylida Infections10aTuberculosis, Pulmonary1 aMarsh B J00aInfectious complications of human T cell leukemia/lymphoma virus type I infection.  a138-450 v233 a<p>Infection with human T cell leukemia/lymphoma virus type I (HTLV-I) has been etiologically associated with two diseases: adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. Increasing evidence suggests that HTLV-I infection may be associated with immunosuppression and, as a consequence, affect the risk and expression of several other infectious diseases, of which the best studied are strongyloidiasis, tuberculosis, and leprosy. In strongyloidiasis, coinfection with HTLV-I appears to result in a higher rate of chronic carriage, an increased parasite load, and a risk of more severe infection. In tuberculosis, a decrease in delayed-type hypersensitivity to Mycobacterium tuberculosis has been established, but whether this decrease is clinically significant has yet to be determined. In leprosy, an increased risk of disease is suggested, but the published studies are all too poorly controlled to draw definite conclusions.</p>  a1058-4838