01918nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653000900080653001000089653001100099653001100110653001200121653000900133653001600142653001800158653001700176653002200193653001800215100001600233700001400249700001600263700001600279245007600295300001000371490000800381520118900389022001401578       1996                            d  c1996 Jul10aAdolescent10aAdult10aAged10aChild10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aMotor Neurons10aNerve Fibers10aNeural Conduction10aReaction Time1 aThacker A K1 aChandra S1 aMukhija R D1 aSarkari N B00aElectro-physiological evaluation of nerves during reactions in leprosy.  a530-50 v2433 a<p>Forty-two patients with leprosy (7 with tuberculoid type, 30 borderline, 5 lepromatous) were studied electrophysiologically during reactions. Thirty-three had type I reactions while 9 had type II reactions. Each patient received 60 mg/day prednisolone tapered over a 6-week period. Motor conduction studies were performed on one clinically affected and one unaffected nerve and were repeated 12 weeks after the beginning of steroid therapy. Significant motor conduction abnormalities were observed in 14 affected (33.3%) and 8 unaffected nerves (19.1%). The majority of these nerves were in patients with borderline leprosy having type I reactions. Following steroid therapy, nerve function improved in 14 affected (33.3%) and 20 unaffected nerves (47.66%). However, 5 affected (10.2%) and 12 unaffected nerves (28.5%) showed a worsening of nerve function following steroid therapy. The majority of the nerves that showed improvement with steroid therapy had type I reactions, while those that showed deterioration had type II reactions. Steroids improved nerve function mainly in patients with type I reactions. Their role in patients with type II reactions remains debatable.</p>  a0340-5354