02438nas a2200349   4500000000100000008004100001260001300042653002100055653001300076653002000089653001100109653001100120653001700131653001200148653000900160653003200169653001500201653001800216100001400234700001200248700001500260700001300275700001400288700001300302700001400315245007900329856004100408300001100449490000700460520160700467022001402074       1996                            d  c1996 Sep10aActinomycetaceae10aBacillus10aCorynebacterium10aFemale10aHumans10aInflammation10aleprosy10aMale10aMicrobial Sensitivity Tests10aSkin Ulcer10aStreptococcus1 aSturm A W1 aJamil B1 aMcAdam K P1 aKhan K Z1 aParveen S1 aChiang T1 aHussain R00aMicrobial colonizers in leprosy skin ulcers and intensity of inflammation.  uhttp://ila.ilsl.br/pdfs/v64n3a04.pdf  a274-810 v643 a<p>The microflora of 55 patients with leprosy skin ulcers was studied and related to a weighted inflammatory score (IS). The control group consisted of 18 ulcers with different underlying pathology. Leprosy ulcers were characterized by the exclusive presence of two types of branching gram-positive rods; a particular interesting proposal is that Mycobacterium leprae share common antigens with these unusual "leprosy ulcer associated" organisms and group G beta-hemolytic streptococci. In the leprosy group, corynebacteria and branching rods accounted for 97% of gram-positive bacilli and Bacillus species constituted only 3%. In the control group, B. species formed 50% of gram-positive rods; the rest were corynebacteria (p = 0.03). In the leprosy group, one third of the gram-positive bacteria were branching rods; none of them was acid fast. Ten of them were identified as Arcanobacterium haemolyticum, and the remaining 7 could not be identified. The IS of leprosy patients was lower than in the control group. The presence of more than two species of facultative or aerobic gram-negative rods or single species of pyogenic gram-positive cocci correlated with a high IS. The presence of two or more different pyogenic cocci resulted in a lower IS. Further studies into the nature of leprosyunique organisms as well as the inflammation inhibition factors in mixed infections are warranted. It is recommended that management of ulcers should consist of the application of local disinfection and early treatment of episodes of inflammation with a combination of fluoroquinolone and penicillin.</p>
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