01917nas a2200349   4500000000100000008004100001260000900042653001000051653001100061653001100072653001100083653001600094653001300110653002300123653001200146653000900158653001600167653002200183653003900205653000900244100001300253700001600266700001400282700001300296700001700309700001600326245006000342300001100402490000600413520113400419022001401553       1995                            d  c199510aAdult10aBiopsy10aFemale10aHumans10aHypesthesia10aLepromin10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aPeripheral nerves10aPeripheral Nervous System Diseases10aSkin1 aMishra B1 aMukherjee A1 aGirdhar A1 aHusain S1 aMalaviya G N1 aGirdhar B K00aNeuritic leprosy: further progression and significance.  a187-940 v93 a<p>Sixteen neuritic cases have been seen developing cutaneous lesions. These cutaneous lesions by and large appear within 4 months after the diagnosis of neuritic leprosy. Leprosy pathology in cutaneous lesions has been found ranging between indeterminate and borderline lepromatous group. Development of cutaneous lesions does not seem to be influenced by age, sex or number of nerves or lepromin status. Neither lesions seem to appear in any particular part of the body. Therapy, duration and type i.e. monodrug or multidrug, also does not seem to influence the development of cutaneous lesions in either way. It appears that neuritic cases with either very early (indeterminate) or with advanced multibacillary neural pathology may develop skin lesions. Skin lesion possibly appear following reversal reaction in skin. Cases with newly developed skin lesions well respond to standard therapy. Development of cutaneous lesions by neuritic cases possibly indicates towards the natural history of the disease, conforming to the hypothesis that leprosy is basically neural in inception and that all other forms emerge from it.</p>  a0001-5938