01518nas a2200313   4500000000100000008004100001260001600042653002100058653000900079653001200088653002200100653001100122653001300133653001100146653001200157653000900169653001600178100001200194700001100206700001600217700001500233700001200248700001300260245012100273300001000394490000800404520077800412022001401190       1996                            d  c1996 Apr 0510aAge Distribution10aAged10aAlleles10aApolipoproteins E10aFemale10agenotype10aHumans10aleprosy10aMale10aMiddle Aged1 aEndoh M1 aUeki A1 aTakahashi K1 aYamanaka H1 aIzumi S1 aTabira T00aSignificantly increased frequency of the apolipoprotein E epsilon 4 allele in elderly non-demented leprosy patients.  a206-80 v2073 a<p>Apolipoprotein E (apo E) genotypes in 350 leprosy patients were examined and compared with those of 870 age-matched controls. The allelic frequencies of the apo E gene did not differ between demented patients with leprosy and controls. However, the frequency of apo E epsilon 4 allele was significantly higher in non-demented leprosy patients than in controls (P < 0.001). Of special interest is that the prevalence of E3/4 genotype in non-demented leprosy patients increased significantly with age, being 14.1%, 24.4%, and 28.3% in the 60s, 70s, and 80s, respectively (P < 0.05). These data suggest that apo E epsilon 4 is not a risk factor for senile dementia in elderly leprosy patients, and there exist factors to overcome the risk of apo E4 in leprosy patients.</p>  a0304-3940