01457nas a2200289   4500000000100000008004100001260001300042653002600055653001400081653002400095653001100119653001200130653002500142653003200167100001300199700001400212700001500226700001500241700001600256245006500272856005900337300001100396490000700407050003200414520070700446022001401153       1996                            d  c1996 Jun10aAntibodies, Bacterial10aCeramides10aGalactosylceramides10aHumans10aleprosy10aMycobacterium leprae10aSensitivity and Specificity1 aVemuri N1 aViera L M1 aTaneja K K1 aGangal S V1 aMukherjee R00aAntisphingolipid antibodies in the sera of leprosy patients.  uhttp://leprev.ilsl.br/pdfs/1996/v67n2/pdf/v67n2a02.pdf  a95-1030 v67  aInfolep Library - available3 a<p>Earlier we reported the presence of significant levels of antigalactocerebroside (GalC) antibodies in the sera of leprosy patients. This study corroborates the above result and also gives evidence for the presence of antibodies to the nonpolar ceramide (Cer) moiety of GalC. AntiCer antibody titres were higher as compared to antiGalC antibodies in all categories of leprosy. The specificity of antibodies directed to the Cer moiety was confirmed using Lactosyl-BSA and neutralization assays. Statistically significant and positive correlations were observed between antiGalC and antiCer antibodies. Responsiveness factors were computed using natural logarithmic transformation of the variables.</p>  a0305-7518