01509nas a2200349   4500000000100000008004100001260001700042653001000059653000900069653001200078653001900090653001600109653002900125653001100154653001100165653002100176653002100197653001200218653002500230653000900255653001600264653002200280100001400302700001400316700001300330245010400343300001200447490000700459050003200466520064700498022001401145       1995                            d  c1995 Jul-Sep10aAdult10aAged10aAnimals10aAutoantibodies10aBCG Vaccine10aCarcinoma, Squamous Cell10aFemale10aHumans10aImmunoglobulin G10aImmunoglobulin M10aleprosy10aLeprosy, lepromatous10aMale10aMiddle Aged10aPeripheral nerves1 aDesikan P1 aParkash O1 aNarang P00aRole of antineural antibodies in perpetuation of a pre-existing peripheral nerve damage in leprosy.  a293-3000 v67  aInfolep Library - available3 a<p>This study was carried out in order to find out whether antineural antibodies had a role to play in perpetuating pre-existing nerve damage in leprosy. Indirect ELISA was carried out on sera from 20 leprosy patients and five normal controls using antigen prepared from peripheral nerves of a cured bacteriologically negative leprosy patient. None of the patients had significant levels of IgG antibodies whereas eight of them (40%) had significant levels of IgM antibodies. However, there was no correlation with duration of disease, treatment received, nerve enlargement or active neuritis. The nature of these antibodies is discussed.</p>  a0254-9395