01397nas a2200253   4500000000100000008004100001260001300042653001200055653002700067653001200094653000900106653001500115653002500130100001100155700001200166700000900178700001000187700001000197245008000207300001000287490000700297520082500304022001401129       1995                            d  c1995 Sep10aAnimals10aDisease Models, Animal10aleprosy10aMice10aMice, Nude10aMycobacterium leprae1 aWang H1 aZhang W1 aYu L1 aShi M1 aLiu J00aStudy on nude mice inoculated with Mycobacterium leprae by multiple routes.  a165-80 v103 a<p>Immune-deficient nude mice were inoculated with nude mouse derived Mycobacterium leprae by multiple routes (intravenously, subcutaneously at the foot pads and ears). The results showed that these inoculated animals were capable of producing a great number of Mycobacterium leprae to a level 10 per gram of tissue and were detected histopathologically to have heavy lepromatous lesions. The dissemination of the infection was found particularly in sites with lower body temperature. The organisms have a partiality to striated muscles and peripheral nerves. The authors suggest that experimental leprosy in nude mice is a very useful tool for leprosy research, especially in countries without armadillos. Compared with the single-route inoculation reported previously, multiple-route inoculation is more available.</p>  a1001-9294