02123nas a2200349   4500000000100000008004100001260001300042653001200055653003100067653003100098653001100129653002800140653001200168653002600180653002300206653000900229653002400238653001500262653002500277653001100302100001200313700001400325700001100339700001300350700001200363245014900375856004100524300001100565490000700576520117600583022001401759       1995                            d  c1995 Dec10aAnimals10aCD4-Positive T-Lymphocytes10aCD8-Positive T-Lymphocytes10aFemale10aImmunotherapy, Adoptive10aleprosy10aLymphocyte Activation10aLymphocyte Subsets10aMice10aMice, Inbred BALB C10aMice, Nude10aMycobacterium leprae10aSpleen1 aMaw W W1 aTomioka H1 aSato K1 aYamada Y1 aSaito H00aStudy on the roles of CD4+ and CD8+ T cells in the expression of host resistance to Mycobacterium leprae infection induced in athymic nude mice.  uhttp://ila.ilsl.br/pdfs/v63n4a05.pdf  a539-450 v633 a<p>The contribution of CD4+ or CD8+ T cells in the host resistance to Mycobacterium leprae was investigated. Athymic BALB/c nude mice were infected subcutaneously with M. leprae into the foot pads 1 or 3 weeks after adoptive transfer with whole, CD4 T cell-depleted, or CD8 T cell-depleted lymphocyte fractions prepared from spleen cells (SPCs) of euthymic BALB/c mice. SPCs from all of the recipient mice showed nearly the same levels of proliferative responses to phytohemagglutinin (PHA) and lipopolysaccharide, except that those of mice transferred with CD4 T cell-depleted lymphocytes showed somewhat reduced mitogenic responses to PHA. Significantly potentiated host resistance to the infection was seen, as evidenced by the obviously reduced bacterial growth in all three groups of recipient mice compared to that seen in control mice, that is, 4.7- to 6.4-log unit decreases in the bacterial loads were observed. Levels of the reduction conferred by CD 4 T cell-depleted lymphocytes were comparable to that of CD8 T cell-depleted lymphocytes. This suggests that both CD4 and CD8 T cells are important for the expression of resistance to M. leprae infection.</p>
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