01328nas a2200289   4500000000100000008004100001260001300042653001000055653001100065653001600076653002100092653002300113653001100136653002200147653001200169653000900181653001600190100001100206700001300217700001300230700001400243245006800257300001100325490000700336520068100343022001401024       1977                            d  c1977 Mar10aAdult10aBiopsy10aCapillaries10aErythema Nodosum10aGlomerulonephritis10aHumans10aKidney Glomerulus10aleprosy10aMale10aMiddle Aged1 aDate A1 aThomas A1 aMathai R1 aJohny K V00aGlomerular pathology in leprosy. An electron microscopic study.  a266-720 v263 a<p>Electron microscopic examination of renal biopsies from 19 patients with leprosy who had edema, proteinuria, or hematuria showed a proliferative glomerulonephritis in 12, amyloidosis in 2, and no lesion in 5. The proliferative glomerulonephritis was of different patterns: diffuse with or without exudation, focal, or mesangial. Subendothelial and/or subepithelial deposits were seen in five biopsies. Of the patients with glomerulonephritis, 3 had a reduced total serum complement level, 5 had erythema nodosum leprosum, 5 had evidence of recent streptococcal infection, and 2 had microfilariae in the peripheral blood. The significance of these findings is discussed.</p>  a0002-9637