01308nas a2200313   4500000000100000008004100001260000900042653001200051653004100063653002900104653002800133653002100161653002300182653002400205653002600229653001200255653000900267653002500276653001700301100001600318700001600334700001100350700001200361245009900373300001000472490000700482520049100489022001400980       1993                            d  c199310aAnimals10aAntibody-Dependent Cell Cytotoxicity10aAntigen-Antibody Complex10aColony Count, Microbial10aImmune Tolerance10aImmunity, Cellular10aIn Vitro Techniques10aKiller Cells, Natural10aleprosy10aMice10aMycobacterium leprae10aTime Factors1 aVaishnavi C1 aGanguly N K1 aKaur S1 aKumar B00aSuppression of ADCC by immune complexes formed in vitro in Mycobacterium leprae-infected mice.  a49-530 v373 a<p>Antibody-dependent cellular cytotoxicity (ADCC) was assessed in mice infected experimentally with Mycobacterium leprae and injected simultaneously with in vitro-formed immune complexes (IC). Significant decrease in the ADCC function was observed in animals given IC at zero day (0dIC) and 3 months (3mIC) post inoculation with M. leprae, when ADCC activity was assessed at 3, 6 and 9 months period. From the data obtained we believe that ADCC is suppressed by IC formed in vitro.</p>  a0385-5600