01423nas a2200277   4500000000100000008004100001260001300042653001200055653002700067653001100094653002200105653001200127653001600139653000900155653002500164653001600189653001800205653002000223100001500243245009000258856004100348300000900389490000700398520072600405022001401131       1993                            d  c1993 Mar10aAnimals10aDisease Models, Animal10aFemale10aImmunosuppression10aleprosy10aMacrophages10aMice10aMicroscopy, Electron10aNerve Crush10aSciatic Nerve10aSilicon Dioxide1 aShetty V P00aAnimal model to study the mechanism of nerve damage in leprosy--a preliminary report.  uhttp://ila.ilsl.br/pdfs/v61n1a12.pdf  a70-50 v613 a<p>Intraneural injection of 10-20 x 10(6) viable Mycobacterium leprae into the sciatic nerve of normal, unsensitized, Swiss white mice gives rise to a tuberculoid type of granulomatous response in 2 weeks. The same dose of viable M. leprae when injected into the sciatic nerves of unsensitized immunosuppressed mice (T200 x 5R) elicited a macrophage response. When macrophages were systemically immobilized using an intraperitoneal injection of silica quartz dust in normal mice, the lesion produced was of the lepromatous type, suggesting a role for the macrophage in the induction of the tuberculoid type of granulomatous response. In all of these in situ experiments, M. leprae failed to enter the Schwann cells.</p>
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