01743nas a2200277   4500000000100000008004100001260001300042653002800055653001000083653002000093653001100113653001100124653001200135653000900147653001600156653001400172653002400186653002000210653001000230100001500240245011000255300001000365490000700375520106900382022001401451       1993                            d  c1993 Mar10aAdministration, Topical10aAdult10aChronic Disease10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aPhenytoin10aProspective Studies10aSodium Chloride10aUlcer1 aBansal N K00aComparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy.  a210-30 v323 a<p><b>BACKGROUND: </b>Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient.</p><p><b>METHODS: </b>The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline.</p><p><b>RESULTS: </b>Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group.</p><p><b>CONCLUSIONS: </b>This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers.</p>  a0011-9059