01684nas a2200313   4500000000100000008004100001260001300042653002300055653002100078653001100099653001800110653002500128100001500153700001400168700001500182700001400197700001200211700001600223700001600239700001200255700001500267245011100282856005900393300000900452490000700461050001500468520087300483022001401356       1993                            d  c1993 Mar10aBacterial Vaccines10aErythema Nodosum10aHumans10aImmunotherapy10aLeprosy, lepromatous1 aZaheer S A1 aMisra R S1 aSharma A K1 aBeena K R1 aKar H K1 aMukherjee A1 aMukherjee R1 aWalia R1 aTalwar G P00aImmunotherapy with Mycobacterium w vaccine decreases the incidence and severity of type 2 (ENL) reactions.  uhttp://leprev.ilsl.br/pdfs/1993/v64n1/pdf/v64n1a02.pdf  a7-140 v64  aZAHEER19933 a<p>Immunotherapy with Mycobacterium w (M.w) vaccine was given to 45 patients with multibacillary (MB) leprosy; 41 similarly classified patients served as controls. All patients received standard multidrug therapy (MDT). Incidence, severity and frequency of type 2 (ENL) reactional episodes were monitored in both groups in a follow-up extending up to 4 years. Reactions were seen in fewer vaccinated (10/37) BL and LL patients than in the control group (12/34). A total of 20 episodes were recorded in the vaccine group as against 29 in the controls, 75% of reactions were mild in vaccinated and 51.72% were mild in the control group patients, and 3 patients in the control group had more than 3 reactional episodes. None of the vaccinated patients showed this. No additional incidence of neuritis were seen among vaccinated individuals during reactional episodes.</p>  a0305-7518