01754nas a2200301   4500000000100000008004100001260001300042653002500055653001200080653001900092653001200111653002200123653003100145653001100176653001200187653000900199653002500208653001300233100001500246700002300261700001700284245012600301856004100427300001000468490000700478520095300485022001401438       1993                            d  c1993 Mar10aAdministration, Oral10aAnimals10aClarithromycin10aDapsone10aDrug Interactions10aDrug Resistance, Microbial10aFemale10aleprosy10aMice10aMycobacterium leprae10aRifampin1 aWalker L L1 aVan Landingham R M1 aShinnick T M00aClarithromycin is bactericidal against strains of Mycobacterium leprae resistant and susceptible to dapsone and rifampin.  uhttp://ila.ilsl.br/pdfs/v61n1a10.pdf  a59-650 v613 a<p>The anti-Mycobacterium leprae activity of clarithromycin when administered alone and in combination with rifampin and dapsone in the diet was determined using the kinetic method of drug evaluation in mice. Clarithromycin when administered at a concentration of 0.1% (w/w) in the diet completely prevented growth of 2 pan-susceptible, 3 dapsone-resistant, 2 rifampin-resistant, and 2 rifampin and dapsone double resistant strains of M. leprae. A 0.03% (w/w) concentration also completely prevented growth of M. leprae in all mice infected with 2 of 7 strains tested, but in only some of the mice infected with the remaining 5 strains. No antagonistic drug interactions were observed between clarithromycin and dapsone or rifampin. The addition of clarithromycin to the currently recommended multidrug regimen should improve the rate of killing of M. leprae and help to prevent the growth of dapsone-resistant and rifampin-resistant strains.</p>
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