01503nas a2200337   4500000000100000008004100001260001600042653002100058653001200079653002400091653001600115653002800131653000900159653001700168653001200185653000900197653002400206653001500230653002500245653002400270100001200294700001500306700001600321700001200337700001300349245012400362300001100486490000700497520064700504022001401151       2000                            d  c2000 Jan 3110aAcyltransferases10aAnimals10aAntigens, Bacterial10aBCG Vaccine10aColony Count, Microbial10aFoot10aImmunization10aleprosy10aMice10aMice, Inbred BALB C10aMice, Nude10aMycobacterium leprae10aVaccines, Synthetic1 aOhara N1 aMatsuoka M1 aNomaguchi H1 aNaito M1 aYamada T00aInhibition of multiplication of Mycobacterium leprae in mouse foot pads by recombinant Bacillus Catmette-Guérin (BCG).  a1294-70 v183 a<p>Immunization of mice with recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) which over-produces a putative protective antigen candidate, the A component of antigen 85 complex (Ag85A), reduced the multiplication of Mycobacterium leprae in the foot pads of mice. The inhibition by this rBCG (rBCG/85A) was more evident than that with parental BCG. Repeated rBCG/85A immunization significantly could reduce M. leplae multiplication in mice. This is first report of rBCG to control mycobacterial infection in animal model. Therefore, rBCG technique may be useful for the development of a more effective mycobacteria vaccine.</p>  a0264-410X