01438nas a2200337   4500000000100000008004100001260001300042653002800055653001500083653001000098653000900108653001100117653001500128653001100143653001900154653001200173653000900185653001600194653001400210653001200224653001800236100001400254700001600268700001400284700001000298245010900308300001000417490000700427520065200434022001401086       1993                            d  c1993 Jun10aAdministration, Topical10aAdolescent10aAdult10aAged10aFemale10aFoot Ulcer10aHumans10aImmobilization10aleprosy10aMale10aMiddle Aged10aPhenytoin10aPowders10aWound Healing1 aMenezes J1 aRajendran A1 aJacob A J1 aVaz M00aThe use of topical phenytoin as an adjunct to immobilization in the treatment of trophic leprosy ulcers.  a340-20 v243 a<p>A total of 30 leprosy patients (controls n = 16; topical phenytoin n = 14) with trophic ulcers on the feet were investigated to ascertain the efficacy of topical phenytoin powder in the healing of ulcers. The ulcers in the two groups were matched for initial size. Healing patterns were assessed by determining changes in depth and planar (surface) dimensions at weekly intervals over a three week study period. Results indicate that while immobilization of the ulcer site is effective in promoting ulcer healing, additional use of topical phenytoin accelerates the healing process. There may however be non-responders to topical phenytoin.</p>  a0125-1562