01635nas a2200277   4500000000100000008004100001260001700042653001100059653002900070653003600099653001500135653001100150653001600161653001200177100001600189700001700205700001500222700001800237700001900255245005900274300001200333490000700345050003200352520095900384022001401343       1993                            d  c1993 Jul-Sep10aBiopsy10aCarcinoma, Squamous Cell10aCell Transformation, Neoplastic10aFoot Ulcer10aHumans10aHyperplasia10aleprosy1 aBobhate S K1 aMadankar S T1 aParate S N1 aChoudhary R K1 aKumbhalkar D T00aMalignant transformation of plantar ulcers in leprosy.  a297-3030 v65  aInfolep Library - available3 a<p>Malignant transformation of plantar ulcers in leprosy is not uncommon. The apparent rarity of these neoplasms could be because many observed cases are not reported. To determine the extent of the problem, 133 consecutive cases of plantar ulcers seen over two years were studied clinically as well as histologically. Plantar ulcers were more common in the distal third of foot (64.67%) but malignant transformation was seen more often in plantar ulcers of proximal third of foot (64.29%). Malignant transformation was more common in plantar ulcers of long duration. Histologically, most of the lesions were benign, being instances of pseudo-epitheliomatous hyperplasia (57.89%) or atypical pseudo-epitheliomatous hyperplasia (13.53%). However, squamous cell carcinoma was observed in 10.53% cases. Thus it may be that more cases with this complication will be detected if it is borne in mind that malignant change may be encountered in such ulcers.</p>  a0254-9395