01459nas a2200337   4500000000100000008004100001260001300042653001200055653001500067653002300082653001600105653002700121653001100148653001200159653001300171653001200184653001400196653000900210653002500219100001200244700001600256700001100272700001500283700001700298245010100315856004100416300001000457490000700467520063300474022001401107       1993                            d  c1993 Sep10aAnimals10aArmadillos10aBacterial Vaccines10aBCG Vaccine10aDisease Models, Animal10aFemale10aFlorida10aLepromin10aleprosy10aLouisiana10aMale10aMycobacterium leprae1 aJob C K1 aSanchez R M1 aHunt R1 aTruman R W1 aHastings R C00aArmadillos (Dasypus novemcinctus) as a model to test antileprosy vaccines; a preliminary report.  uhttp://ila.ilsl.br/pdfs/v61n3a03.pdf  a394-70 v613 a<p>The efficacy of two candidate leprosy vaccines, BCG and a mixture of BCG and killed Mycobacterium leprae, was tested in 62 armadillos caught in the wild. The abilities of the vaccines to convert lepromin-negative armadillos to a positive reaction were compared with a group of control animals. Both vaccines upgraded subsequent lepromin skin-test histopathology. The conversion results parallel the protection values obtained in some BCG vaccine trials against leprosy in humans. Before conducting expensive human trials with new antileprosy vaccines, it would be worthwhile first to evaluate them in the armadillo model.</p>  a0148-916X