01764nas a2200337   4500000000100000008004100001260001300042653001900055653001100074653001100085653001200096653003400108653000900142653001600151653002800167100001800195700001800213700002300231700001600254700001900270700001700289700001600306700001200322245005400334856005900388300001200447490000700459050003200466520091400498022001401412       1993                            d  c1993 Sep10aAutoantibodies10aFemale10aHumans10aleprosy10aLupus Erythematosus, Systemic10aMale10aMiddle Aged10aTuberculosis, Pulmonary1 aKroumpouzos G1 aVareltzidis A1 aKonstadoulakis M M1 aAvgerinou G1 aAnastasiadis G1 aKroubouzou H1 aPanteleos A1 aTosca A00aEvaluation of the autoimmune response in leprosy.  uhttp://leprev.ilsl.br/pdfs/1993/v64n3/pdf/v64n3a03.pdf  a199-2070 v64  aInfolep Library - available3 a<p>Immunological responses to a panel of antigens were evaluated in 27 patients with lepromatous and 20 patients with tuberculoid leprosy and compared with 24 pulmonary tuberculosis patients, 25 systemic lupus erythematosus patients and 41 healthy blood donors. Some autoantibody specificities were extensively studied for the first time in mycobacterial infections. Striking immunoserological abnormalities were found in patients with lepromatous leprosy, particularly in those presenting with relapse. Inhibition assays were performed, providing a tool for further analysis of the binding range of specific anti-N.D.O. BSA antibodies and strengthening the suggestion of molecular mimicry reactions between cytoskeletal proteins, host stress proteins and Mycobacterium leprae antigens or stress proteins. A significant serological overlap between lepromatous leprosy and autoimmune diseases is indicated.</p>  a0305-7518