01252nas a2200289   4500000000100000008004100001260001300042653002600055653001800081653001100099653001200110653001200122653002700134653002500161653001800186653002200204653003900226653002100265653003200286653001800318100001700336245007200353300000900425490000600434520050800440022001400948       2000                            d  c2000 Jan10aCytoskeletal Proteins10aDystroglycans10aHumans10aLaminin10aleprosy10aMembrane Glycoproteins10aMycobacterium leprae10aMyelin Sheath10aPeripheral nerves10aPeripheral Nervous System Diseases10aProtein Isoforms10aProtein Structure, Tertiary10aSchwann Cells1 aRambukkana A00aHow does Mycobacterium leprae target the peripheral nervous system?  a23-80 v83 a<p>Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.</p>  a0966-842X