01259nas a2200313   4500000000100000008004100001260001300042653001200055653002600067653002600093653002800119653002700147653002100174653001200195653000900207653001500216653003200231653002500263653001400288653001500302100002800317700001700345245010600362856004100468300001000509490000700519520040500526022001400931       1993                            d  c1993 Dec10aAnimals10aAnti-Infective Agents10aAntitubercular Agents10aColony Count, Microbial10aDisease Models, Animal10aFluoroquinolones10aleprosy10aMice10aMice, Nude10aMicrobial Sensitivity Tests10aMycobacterium leprae10aOfloxacin10aQuinolones1 aMcDermott-Lancaster R D1 aBanerjee D K00aActivity of sparfloxacin against Mycobacterium leprae measured by the proportional bactericidal test.  uhttp://ila.ilsl.br/pdfs/v61n4a12.pdf  a605-80 v613 a<p>The activity of 25 mg/kg and 50 mg/kg sparfloxacin was measured against Mycobacterium leprae in normal (immunocompetent) mouse foot pads by the proportional bactericidal test. This was compared with the action of 25, 50, and 150 mg/kg ofloxacin by the same method. Sparfloxacin, at both concentrations, was found to be strongly bactericidal by this method, comparable to 150 mg/kg ofloxacin.</p>
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