01883nas a2200385   4500000000100000008004100001260001300042653001200055653002800067653001100095653001300106653002800119653001200147653001600159653002600175653001600201653000900217653000900226653002400235653004500259653002500304653003200329653001100361653002400372653001600396100001100412700001200423700001300435700001400448245008500462300000900547490000700556520092000563022001401483       1994                            d  c1994 Jan10aAnimals10aColony Count, Microbial10aFemale10aGlutaral10aImmunotherapy, Adoptive10aleprosy10aLymph Nodes10aLymphocyte Activation10aLymphocytes10aMale10aMice10aMice, Inbred BALB C10aMycobacterium Infections, Nontuberculous10aMycobacterium leprae10aNontuberculous Mycobacteria10aSpleen10aTissue Preservation10aVaccination1 aLevy L1 aEnk C D1 aZipris D1 aCohen I R00aProtection of mice against mycobacterial infection by lymphoid cell vaccination.  a22-50 v303 a<p>Intracellular parasites may thrive by inducing the host's immune system to suppress the effector immune response that otherwise limits multiplication. Hosts are traditionally immunized with the parasite antigens that induce effector immunity. Alternatively, one might vaccinate the host with the host lymphoid cells involved in suppression. Multiplication of Mycobacterium marinum was prevented by vaccinating mice with cells prepared from the popliteal lymph nodes of mice in which the organisms were multiplying logarithmically, that were inactivated by fixation with glutaraldehyde. Cells obtained later during infection, when the donor mice manifest immunity, did not protect against infection. Thus, it may be possible to influence the course of a microbial infection by immunizing the host not only with components of the organisms, but also with the host components that are exploited by the organism.</p>  a0021-2180