01943nas a2200361   4500000000100000008004100001260000900042653001500051653001100066653002900077653002000106653001100126653000900137653001800146653001500164653001100179653001600190653001200206653000900218653001600227653002600243653001200269653001900281100001600300700001400316700001700330700001500347245007700362300001000439490000600449520111200455022001401567       1994                            d  c199410aAmputation10aBiopsy10aCarcinoma, Squamous Cell10aChronic Disease10aFemale10aFoot10aFoot Diseases10aFoot Ulcer10aHumans10aHyperplasia10aleprosy10aMale10aMiddle Aged10aRetrospective Studies10aSenegal10aSkin Neoplasms1 aGrauwin M Y1 aGentile B1 aChevallard A1 aCartel J L00a[Characterization of chronic plantar ulcers in former leprosy patients].  a25-300 v93 a<p>Between 1988 and 1992, 21 biopsies for pathological examination were taken from 20 Senegalese leprosy patients suffering from chronic plantar ulcers (CPU) suspected of malignant transformation. The diagnosis of squamous cell carcinoma was effectively made in 13 cases and that of pseudoepitheliomatous hyperplasia in the remaining 8 cases. The mean period of time between the onset of CPU and that of malignant transformation was 10 years (range: 1 to 15 years); the mean annual frequency of the malignant transformation was 2 per 1,000 CPU. In countries where pathological examination is not available, below knee amputation could be considered whenever main clinical signs of malignant transformation are present. In countries where pathological examination is available, the therapeutic decision may differ according to the diagnosis: below knee amputation supplemented with block dissection of inguinal lymph nodes whenever possible in cases of carcinoma; below knee amputation depending on the function status of the foot and on the volume of tumor in case of pseudo-epitheliomatous hyperplasia.</p>  a0001-5938