01682nas a2200289   4500000000100000008004100001260001300042653003100055653001300086653002400099653001100123653002800134653001200162653001800174653002400192653003100216653001500247653002000262100001300282700001700295700001700312245003800329300001000367490000700377520099400384022001401378       1975                            d  c1975 Aug10aAntigen-Antibody Reactions10aAntigens10aAntigens, Bacterial10aHumans10aInjections, Intradermal10aleprosy10aMycobacterium10aMycobacterium avium10aMycobacterium tuberculosis10aSkin Tests10aTuberculin Test1 aPaul R C1 aStanford J L1 aCarswell J W00aMultiple skin testing in leprosy.  a57-680 v753 a<p>Groups of patients with lepromatous and tuberculoid leprosy and hospital staff from six leprosaria in East Africa and 'non-contact' groups of villagers or staff from general hospitals have been skin tested with 10 reagents. These were prepared by ultrasonic disintegration from M. tuberculosis, M. duvalii, M. chelonei and 7 other species identified in the Ugandan environment. Comparisons were made of the percentages of positive reactors in each study group for each reagent. The 'specific' defect of lepromatous patients was found to apply to a variable extent to six of the species tested, but not to M. tuberculosis, M. avium or M. 'A'. The defect applied most noticeably to M. nonchromogenicum and M. vaccae, suggesting that they are more closely related to M. leprae than are the other species tested. The reagent Chelonin produced unexpected and anomalous results in the lepromatous group. It is suggested that this was due to an unusually slow clearing of Arthus' reaction.</p>  a0022-1724