01910nas a2200313   4500000000100000008004100001260001300042653001600055653001200071653002300083653001700106653001800123653001200141653000900153653001500162653002500177100001200202700001100214700001600225700001500241700001400256245015100270856005900421300001100480490000700491050003200498520105200530022001401582       1993                            d  c1993 Dec10aAmino Acids10aAnimals10aBacterial Vaccines10aImmunization10aKidney Cortex10aleprosy10aMice10aMicrovilli10aMycobacterium leprae1 aKohli M1 aKaur S1 aGanguly N K1 aSharma V K1 aChugh K S00aTransport of amino-acids across renal brush border membrane vesicles in Mycobacterium leprae infected Swiss albino mice--effect of Convit vaccine.  uhttp://leprev.ilsl.br/pdfs/1993/v64n4/pdf/v64n4a05.pdf  a316-240 v64  aInfolep Library - available3 a<p>Brush border membrane vesicles prepared from kidneys of Mycobacterium leprae infected (non-vaccinated) and vaccinated-infected Swiss albino mice were used to assess the effect of Convit's combined vaccine (BCG + M. leprae) on amino acid transport activity across the tubular basement membrane. The protective effect of Convit's vaccine was more pronounced with respect to the uptake of L-alanine than L-aspartate. Uptake of L-lysine showed no significant difference in the different groups. Footpad counts followed characteristic growth curves in the non-vaccinated infected group but showed a lag in the development of peak levels in the vaccinated group. Further Convit's vaccine appeared to have a protective effect on renal impairment in the mouse model of leprosy in the initial stages of infection only, as indicated by the transient reversal of amino acid uptake and a diminution in the footpad counts induced by M. leprae infection. No significant (P > 0.05) protective effect of the vaccine was found in the advanced disease state.</p>  a0305-7518