01478nas a2200301   4500000000100000008004100001260001300042653002800055653001400083653001100097653002800108653002500136653002500161653001800186653000900204653001800213100001200231700001400243700001200257700001500269700001300284245012600297856004100423300001000464490000700474520068100481022001401162       1994                            d  c1994 Jun10aDiagnosis, Differential10aGranuloma10aHumans10aImmunoenzyme Techniques10aLeprosy, Tuberculoid10aMycobacterium leprae10aS100 Proteins10aSkin10aSkin Diseases1 aSingh N1 aArora V K1 aRamam M1 aTickoo S K1 aBhatia A00aAn evaluation of the S-100 stain in the histological diagnosis of tuberculoid leprosy and other granulomatous dermatoses.  uhttp://ila.ilsl.br/pdfs/v62n2a09.pdf  a263-70 v623 a<p>Forty biopsies of granulomatous dermatoses, 12 of which were tuberculoid leprosy (TL), were studied for patterns of nerve twig distribution using an immunoperoxidase technique for S-100 protein. Four distinct patterns of nerve twigs were identified: 1) within granulomas, 2) between granulomas, 3) within and between granulomas, and 4) undetectable nerve twigs in an adequate biopsy. Pattern 4 was seen exclusively in TL (p &lt; 0.05). The other patterns occurred in nonleprosy dermatoses as well, suggesting that pattern 4 is the best indicator toward a diagnosis of TL. The granules of mycetoma and Mycobacterium leprae also stained positively with the S-100 stain.</p>
  a0148-916X