01362nas a2200337   4500000000100000008004100001260001700042653002500059653001200084653001800096653001800114653001600132653001200148653000900160653000900169653001200178653000900190653002400199653002500223653001300248100001700261700001400278700001600292700001600308245009900324856004100423300001100464490000700475520052800482022001401010       1976                            d  c1976 Oct-Dec10aAdministration, Oral10aAnimals10aAscorbic Acid10aCell Division10aClofazimine10aDapsone10aDiet10aFoot10aleprosy10aMice10aMice, Inbred BALB C10aMycobacterium leprae10aRifampin1 aHastings R C1 aRichard V1 aChristy S A1 aMorales M J00aActivity of ascorbic acid in inhibiting the multiplication of M. leprae in the mouse foot pad.  uhttp://ila.ilsl.br/pdfs/v44n4a01.pdf  a427-300 v443 a<p>Ascorbic acid was fed to mice in concentrations of 0.05%, 0.15%, and 0.45% w/w in the diet. Six months after inoculation of M. leprae into the foot pads, there were significantly fewer acid-fast bacilli harvested from animals receiving 0.15% and 0.45% w/w ascorbic acid than from control mice. On the other hand, M. leprae did multiply in mice fed ascorbic acid while no multiplication at all was observed in animals fed dapsone, clofazimine or rifampin. No toxic effects of ascorbic acid were noted in these mice.</p>
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