01308nas a2200301   4500000000100000008004100001260001700042653001000059653000900069653001000078653001200088653001100100653001100111653001000122653001200132653000900144653001600153653001300169100001300182700001300195700002000208245002900228300001000257490000700267050003200274520068600306022001400992       1994                            d  c1994 Jan-Mar10aAdult10aAged10aChild10aDapsone10aFemale10aHumans10aIndia10aleprosy10aMale10aMiddle Aged10aSyndrome1 aRege V L1 aShukla P1 aMascarenhas M F00aDapsone syndrome in Goa.  a59-640 v66  aInfolep Library - available3 a<p>Daspone syndrome was noted within six weeks of starting treatment in 1.3% of about 700 leprosy patients on MDT reporting to the skin department of Goa Medical College. Skin rash, photosensitivity, fever, lymphadenopathy, sore throat, hepatosplenomegaly, abnormal liver function tests and raised reticulocyte count were consistent features in all the patients. Other drugs, infectious mononucleosis and viral exanthemata were considered in differential diagnosis. Withdrawal of dapsone and administration of prednisolone controlled the condition within three to four weeks in majority of the patients. One patient died of ischemic heart disease unrelated to dapsone syndrome.</p>  a0254-9395