01831nas a2200289   4500000000100000008004100001260001300042653002600055653002400081653001100105653002100116653001200137653002400149653002500173653002500198653002400223100001500247700001600262700001300278700001500291245011300306856004100419300001000460490000700470520105000477022001401527       1999                            d  c1999 Dec10aAntibodies, Bacterial10aAntigens, Bacterial10aHumans10aImmunoglobulin G10aleprosy10aLeprosy, Borderline10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aLipopolysaccharides1 aBeuria M K1 aMohanty K K1 aKatoch K1 aSengupta U00aDetermination of circulating IgG subclasses against lipoarabinomannan in the leprosy spectrum and reactions.  uhttp://ila.ilsl.br/pdfs/v67n4a08.pdf  a422-80 v673 a<p>IgG subclasses against lipoarabinomannan of mycobacteria were analyzed in the sera of leprosy patients. Patients with active leprosy [tuberculoid and lepromatous, patients undergoing erythema nodosum leprosum (ENL) and reversal reactions] and inactive cases (tuberculoid and lepromatous who were cured after chemotherapy) were included in this study. Active lepromatous patients had higher levels of IgG subclasses, except IgG4, compared to active tuberculoid patients. Some of the inactive cases (lepromatous patients cured after chemotherapy) were positive for the IgG1, IgG2 and IgG3 subclasses. However, their levels are lower than active lepromatous cases. On the other hand, no difference in the subclass levels between the active and inactive tuberculoid groups could be observed. While a significant fall in the level of IgG3 in ENL was observed as compared to lepromatous leprosy without ENL, higher levels of IgG1 and IgG2 were found in patients with reversal reactions compared to their active counterparts without reactions.</p>
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