02298nas a2200385   4500000000100000008004100001260001300042653002300055653001600078653001100094653003000105653002200135653002200157653001400179653001100193653001000204653001200214653002500226653000900251653001500260653002100275100001600296700001400312700001100326700001500337700001500352700001900367700001100386245011700397856004100514300001100555490000700566520132500573022001401898       1994                            d  c1994 Sep10aBacterial Vaccines10aBCG Vaccine10aBiopsy10aCell Migration Inhibition10aDrug Combinations10aFollow-Up Studies10aGranuloma10aHumans10aIndia10aleprosy10aMycobacterium leprae10aSkin10aSkin Tests10aUrban Population1 aChaudhury S1 aHazra S K1 aSaha B1 aMazumder B1 aBiswas P C1 aChattopadhya D1 aSaha K00aAn eight-year field trial on antileprosy vaccines among high-risk household contacts in the Calcutta metropolis.  uhttp://ila.ilsl.br/pdfs/v62n3a07.pdf  a389-940 v623 a<p>One-hundred-seventy-nine lepromin-negative household contacts were vaccinated with heat-killed Mycobacterium leprae, BCG, or a combination of the two. Vaccination induced lepromin positivity in 131 of these contacts. Over an 8-year follow-up period, 12 lepromin-positive contacts developed leprosy, all tuberculoid; while 2 lepromin-negative vaccinated contacts developed leprosy, both lepromatous. Overall, 7.8% of the vaccinated contacts developed the disease. Seven-hundred-fourteen household contacts were not vaccinated, and served as controls. Among the 504 who were lepromin positive, leprosy developed in 35, all tuberculoid, over the 8-year follow up. Among the 210 lepromin-negative unvaccinated contacts, 61 developed leprosy: tuberculoid in 29, borderline in 4, lepromatous in 8, and indeterminate in 20. Overall, 13.5% of the 714 unvaccinated contacts and 29.0% of the 210 unvaccinated, lepromin-negative contacts developed leprosy. Vaccination could not induce lepromin positivity in all contacts. The three vaccines were equally effective in inducing lepromin positivity. Vaccination reduced the overall incidence of leprosy from 13.5% to 7.8% among household contacts but did not reduce the incidence of lepromatous leprosy (1.2% of all the vaccinated and 1.1% of all the unvaccinated contacts).</p>
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