01910nas a2200313   4500000000100000008004100001260001300042653001800055653003100073653001100104653002300115653002200138653001200160653002000172653002900192653002500221653002900246653002800275100001500303700001400318700001500332700001500347700001100362245015400373300001000527490000700537520103800544022001401582       1994                            d  c1994 Jul10aCD4-CD8 Ratio10aCD4-Positive T-Lymphocytes10aHumans10aImmunity, Cellular10aImmunophenotyping10aleprosy10aLeukocyte Count10aReceptors, Interleukin-210aT-Lymphocyte Subsets10aT-Lymphocytes, Cytotoxic10aTuberculosis, Cutaneous1 aSehgal V N1 aGupta R P1 aKarmakar S1 aLogani K B1 aJain S00aIn situ characterization of lymphocytic immunophenotypes and interleukin-2 receptors in cutaneous tuberculosis and leprosy--a comparative evaluation.  a312-60 v193 a<p>The granulomas of lupus vulgaris (LV) were characterized by preponderance of CD4+ lymphocytes and a raised CD4+/CD8+ ratio. In contrast, in scrofuloderma (SF) the CD8+ T-lymphocyte subpopulation predominated and the CD4+/CD8+ ratio was significantly decreased. A higher percentage of lymphocytes expressed interleukin-2 receptor (IL-2R) in LV as compared with SF, indicating an activated cellular immune response in the former. Immunophenotypic changes in tuberculosis verrucosa cutis (TBVC) were intermediate between LV and SF. CD4+ lymphocytes were the main infiltrating T-cell type in borderline tuberculoid leprosy (BT), while CD8+ lymphocytes predominated in the granuloma of lepromatous lepromatous (LL). The CD4+/CD8+ ratio and percentage of lymphocytes expressing IL-2R was significantly higher in BT as compared with LL. These immunophenotypic findings suggest that in both cutaneous tuberculosis and leprosy there is a continuous spectrum with regard to cell-mediated immunity depending on the clinical presentation.</p>  a0307-6938